Optimized and Redundant Methods of Matching
Matching results that are quick, accurate, and assured
The real strength and value of Silverstone Matchmaker is its ability
to quickly and accurately work with a wide variety of organ transplant clinical
data for the purposes of providing valid recipient/donor cross-match pairing.
Based on three proprietary algorithms, Matchmaker can virtually eliminate the
long process of reviewing clinical data markers by hand for analyzing potential
organ transplants.
The custom algorithms have the capability of performing both 2-way and
3-way cross-comparisons utilizing either the basic 6 HLA antigens (2 copies
each of HLA –A, B and DR), termed the VXM-6 (virtual cross-match
6), or an expanded HLA comparison in the VXM-14 mode (which adds 2 copies
each of HLA-Bw, Cw, DQ and DRw). Using DNA-based HLA antigen determinations
and solid phase single antigen assessment of antigen avoids, a negative
virtual cross-match as defined above predicts a real negative cross-match
with a certainty in the range of 80% to 90%. It’s also possible for
Silverstone Solutions Professional Services to customize HLA antigen cross
compares to match a specified list as dictated by the individual doctor
or clinician.
Multiple algorithms based on separate techniques
are applied simultaneously in a multi-threaded software environment to
provide a level of redundancy not found in other software approaches. This
redundancy assures a very high level of confidence for the doctor and clinician
as they uncover suggested matched pairs.
The parameter matching and recipient/donor cross-matching analysis has been further optimized to allow for extremely fast and efficient match processing on a large clinic data file. Matchmaker has been built with the goal of allowing native operation on a standard-class desktop or notebook computer and does not require the additional purchase of extremely high-end and costly computing equipment.